Journal of Autoimmunity
Papers 3480
1 page of 348 pages (3,480 results)
#1Kristen M. Valentine (UCM: University of California, Merced)H-Index: 4
#2Genevieve N. Mullins (UCM: University of California, Merced)H-Index: 1
Last. Katrina K. Hoyer (UCM: University of California, Merced)H-Index: 16
view all 5 authors...
Abstract null null Follicular CXCR5+ PD-1+ CD8 T cells (CD8 Tfc) arise in multiple models of systemic autoimmunity yet their functional contribution to disease remains in debate. Here we define the follicular localization and functional interactions of CD8 Tfc with B cells during autoimmune disease. The absence of functional T regulatory cells in autoimmunity allows for CD8 Tfc development that then expands with lymphoproliferation. CD8 Tfc are identifiable within the lymph nodes and spleen duri...
#1Amanda Salviano-Silva (UFPR: Federal University of Paraná)
#2Mareike Becker (University of Lübeck)H-Index: 1
Last. Andre Franke (CAU: University of Kiel)H-Index: 120
view all 27 authors...
Abstract null null Background null Pemphigus is a group of bullous diseases characterized by acantholysis and skin blisters. As for other autoimmune diseases, the strongest genetic associations found so far for pemphigus foliaceus (PF) and vulgaris (PV) are with alleles of HLA genes. However, apart from protein-coding genes, the MHC region includes a set of poorly explored long non-coding RNA (lncRNA) genes, the HLA complex group (HCG). null null null Objectives null To investigate if HCG lncRNA...
#1Suqing Zhou (CSU: Central South University)H-Index: 1
#2Qianwen Li (CSU: Central South University)H-Index: 5
Last. Qianjin LuH-Index: 42
view all 7 authors...
Abstract null null Cutaneous lupus erythematosus (CLE) is a relapsing autoimmune disease, but key elements that drive disease initiation and progression remain elusive. To date, the lack of ideal murine model which resemble human cutaneous lupus makes it extremely challenging for moving mechanistic discoveries and novel therapeutics. Here, we prompt a humanized murine model to develop an inducible rapid-onset murine that performs cutaneous rather than systemic lupus, depending on the successful ...
#1Mohamed Rela (Bharath University)H-Index: 35
#2Dinesh Jothimani (Bharath University)H-Index: 2
Last. Ashwin Rammohan (Bharath University)H-Index: 2
view all 5 authors...
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH) can occur in predisposed individuals where an immune mediated reaction against hepatocytes is triggered by enviro...
#1Anne-Charlotte Heba (University of Lorraine)H-Index: 1
#2Simon Toupance (University of Lorraine)H-Index: 5
Last. Ndeye Coumba Ndiaye (University of Lorraine)H-Index: 17
view all 6 authors...
Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that preserve the integrity and stability of the genome. Telomere dysfunctions due to short telomeres or altered telomere structures can ultimately lead to replicative cellular senescence and chromosomal instability, both mechanisms being hallmarks of ageing. Chronic inflammation, oxidative stress and finally telomere length (TL) dynamics have been shown to be involved in various age-related non-communicable disease...
#1Julia R Hirsiger (University of Basel)H-Index: 3
#2Giorgio Tamborrini (UTSW: University of Texas Southwestern Medical Center)
Last. Christoph Hess (University of Basel)H-Index: 40
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Background null Viral infections may trigger autoimmunity in genetically predisposed individuals. Immunizations mimic viral infections immunologically, but only in rare instances vaccinations coincide with the onset of autoimmunity. Inadvertent vaccine injection into periarticular shoulder tissue can cause inflammatory tissue damage ('shoulder injury related to vaccine administration, SIRVA). Thus, this accident provides a model to study if vaccine-induced pathogen-specific immunity accompanied ...
#1Maayan Hemed-Shaked (HUJI: Hebrew University of Jerusalem)
#2Mary K. Cowman (NYU: New York University)H-Index: 34
Last. Libat Bar Lev (HUJI: Hebrew University of Jerusalem)
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Despite the existence of potent anti-inflammatory biological drugs e.g., anti-TNF and anti IL-6 receptor antibodies, for treating chronic inflammatory and autoimmune diseases, these are costly and not specific. Cheaper oral available drugs remain an unmet need. Expression of the acute phase protein Serum Amyloid A (SAA) is dependent on release of pro-inflammatory cytokines IL-1, IL-6 and TNF-α during inflammation. Conversely, SAA induces pro-inflammatory cytokine secretion, including Th17, leadi...
#1Saathvik R. Kannan (MU: University of Missouri)H-Index: 1
#2Austin N. Spratt (MU: University of Missouri)H-Index: 2
Last. Kamal SinghH-Index: 8
view all 0 authors...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been rapidly evolving in the form of new variants. At least eleven known variants have been reported. The objective of this study was to delineate the differences in the mutational profile of Delta and Delta Plus variants. High-quality sequences (n = 1756) of Delta (B.1.617.2) and Delta Plus (AY.1 or B.1.617.2.1) variants were used to determine the prevalence of mutations (≥20 %) in the entire SARS-CoV-2 genome, their co-existence,...
#1Qianjin Lu (Peking Union Medical College)H-Index: 3
#2Hai Long (CSU: Central South University)H-Index: 18
Last. Juan Tao (HUST: Huazhong University of Science and Technology)H-Index: 26
view all 35 authors...
Cutaneous lupus erythematosus (CLE) is an inflammatory, autoimmune disease encompassing a broad spectrum of subtypes including acute, subacute, chronic and intermittent CLE. Among these, chronic CLE can be further classified into several subclasses of lupus erythematosus (LE) such as discoid LE, verrucous LE, LE profundus, chilblain LE and Blaschko linear LE. To provide all dermatologists and rheumatologists with a practical guideline for the diagnosis, treatment and long-term management of CLE,...
#1Renata Baronaite Hansen (Stanford University)
#2Julia F. Simard (Stanford University)H-Index: 35
Last. Søren Jacobsen (UCPH: University of Copenhagen)H-Index: 73
view all 4 authors...
The objective of this study was to assess the cumulative prevalence of pre-existing comorbidities among patients diagnosed with systemic lupus erythematosus (SLE) in Denmark. The study included patients aged ≥18 years at the index date set to the date of first registration of SLE in the Danish National Patient Registry (DNPR) between 1996 and 2018. Up to 19 age- and sex-matched general population comparators per case were selected. Comorbidity diagnoses were retrieved from the DNPR based on Inte...
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