Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development
Abstract
Epigenesis is the process whereby the daughters of a dividing cell retain a chromatin state determined before cell division. The best-studied cases involve the inheritance of heterochromatic chromosomal domains, and little is known about specific gene regulation by epigenetic mechanisms. Recent evidence shows that epigenesis pivots on methylation of nucleosomes at histone 3 lysines 4, 9 or 27. Bioinformatics indicates that mammals have several...
Paper Details
Title
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development
Published Date
Apr 15, 2006
Journal
Volume
133
Issue
8
Pages
1423 - 1432
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