Investigation of tomosynthetic perfusion measurements using the scanning-beam digital x-ray (SBDX) system

Published on Oct 26, 2004
· DOI :10.1117/12.556350
Brian E. Nett15
Estimated H-index: 15
(UW: University of Wisconsin-Madison),
Guang-Hong Chen41
Estimated H-index: 41
(UW: University of Wisconsin-Madison)
+ 5 AuthorsCharles A. Mistretta62
Estimated H-index: 62
(UW: University of Wisconsin-Madison)
Sources
Abstract
The feasibility of making regional perfusion measurements using a tomosynthetic digital subtraction angiography (TDSA) acquisition has been demonstrated. The study of tomosynthetic perfusion measurements was motivated by the clinical desire for perfusion measurements in an interventional angiography suite. These pilot studies were performed using the scanning-beam digital x-ray (SBDX) system which is an inverse-geometry imaging device which utilizes an electromagnetically-scanned x-ray source, and a small CdTe direct conversion photon counting detector. The scanning electron source was used to acquire planar-tomographic images of a 12.5 x 12.5 cm field of view at a frame rate of 15 frames/sec during dynamic contrast injection. A beagle animal model was used to evaluate the tomosynthetic perfusion measurements. A manual bolus injection of iodinated contrast solution was used in order to resolve the parameters of the contrast pass curve. The acquired planar tomosynthetic dataset was reconstructed with a simple back-projection algorithm. Digital subtraction techniques were used to visualize the change in contrast agent intensity in each reconstructed plane. Given the TDSA images, region of interest based analysis was used in the selection of the image pixels corresponding to the artery and tissue bed. The mean transit time (MTT), regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) were extracted from the tomosynthetic data for selected regions in each of the desired reconstructed planes. For the purpose of this study, the arterial contrast enhancement curve was fit with a combination of gamma variate terms, and the MTT was calculated using a deconvolution based on the singular value decomposition (SVD). The results of the contrast pass curves derived with TDSA were consistent with the results from perfusion measurements as implemented with CT acquisition.
📖 Papers frequently viewed together
2007
6 Authors (R. N. Gupta)
References23
Newest
#1Michael Jerosch-Herold (OHSU: Oregon Health & Science University)H-Index: 79
#2Ravi Teja Seethamraju (UMN: University of Minnesota)H-Index: 18
Last. Arthur E. Stillman (UMN: University of Minnesota)H-Index: 41
view all 5 authors...
Rapid MR imaging (MRI) during the first pass of an injected tracer is used to assess myocardial perfusion with a spatial resolution of 2–3 mm, and to detect any regional impairments of myocardial blood flow (MBF) that may lead to ischemia. The spatial resolution is sufficient to detect flow reductions that are limited to the subendocardial layer. The capacity of the coronary system to increase MBF severalfold in response to vasodilation can be quantified by analysis of the myocardial contrast en...
Source
#1James T. Dobbins (Duke University)H-Index: 35
#2Devon J. Godfrey (Duke University)H-Index: 19
Digital x-ray tomosynthesis is a technique for producing slice images using conventional x-ray systems. It is a refinement of conventional geometric tomography, which has been known since the 1930s. In conventional geometric tomography, the x-ray tube and image receptor move in synchrony on opposite sides of the patient to produce a plane of structures in sharp focus at the plane containing the fulcrum of the motion; all other structures above and below the fulcrum plane are blurred and thus les...
Source
#1P KestonH-Index: 1
#2Alison D. MurrayH-Index: 49
Last. Alan Jackson (University of Manchester)H-Index: 114
view all 3 authors...
New developments in fast magnetic resonance imaging (MRI) have enabled imaging of cerebral haemodynamics. This article describes the theory behind perfusion imaging and provides an overview of the most commonly used MRI technique. Limitations of this technique are described, and the potential clinical applications are discussed, with particular attention to the role of perfusion imaging in the context of stroke and brain tumour.
Source
#1Richard E. LatchawH-Index: 57
#2Howard YonasH-Index: 70
Last. George HademenosH-Index: 23
view all 11 authors...
A number of techniques have been developed during the past four decades to evaluate cerebral perfusion. The oldest used 133Xe, a lipophilic radioactive tracer that easily diffuses through the blood-brain barrier (BBB). It was either injected or inhaled, and probes placed over the scalp were used to measure perfusion to the cerebral cortex.1,2 In the mid-1970s, the development of a scanner to detect the emission of positrons led to positron emission tomography (PET) in humans.3 Using a number of ...
Source
#1James D. Eastwood (Duke University)H-Index: 29
#2Michael H. LevH-Index: 82
Last. James M. ProvenzaleH-Index: 98
view all 3 authors...
Source
#1Darius G. Nabavi (Siemens)H-Index: 48
#2Stephan P. Kloska (Siemens)H-Index: 29
Last. E. Bernd Ringelstein (Siemens)H-Index: 66
view all 8 authors...
Background and Purpose— With new CT technologies, including CT angiography (CTA), perfusion CT (PCT), and multidetector row technique, this method has regained interest for use in acute stroke assessment. We have developed a score system based on Multimodal Stroke Assessment Using CT (MOSAIC), which was evaluated in this prospective study. Methods— Forty-four acute stroke patients (mean age, 63.8 years) were enrolled within a mean of 3.0±1.9 hours after symptom onset. The MOSAIC score (0 to 8 po...
Source
#1James D. Eastwood (Duke University)H-Index: 29
#2Michael H. LevH-Index: 82
Last. James M. ProvenzaleH-Index: 98
view all 12 authors...
PURPOSE: To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging. MATERIALS AND METHODS: Twelve patients with acute middle cerebral artery stroke and 12 control patients were examined by using single-section computed tomography (CT) perfusion scanning. Analysis was performed with a deconvolution-based algorithm. Comparisons of mean CBF, cerebral blood volume (...
Source
#1Kenya Murase (Osaka University)H-Index: 47
#2Masaaki ShinoharaH-Index: 4
Last. Youichi YamazakiH-Index: 11
view all 3 authors...
Deconvolution analysis (DA) based on singular value decomposition (SVD) has been widely accepted for quantification of cerebral blood flow (CBF) using dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI). When using this method, the elements in the diagonal matrix obtained by SVD are set to zero when they are smaller than the threshold value given beforehand. In the present study, we investigated the effect of the threshold value on the accuracy of the CBF values obtaine...
Source
#1Heidi C. Roberts (UCSF: University of California, San Francisco)H-Index: 35
#2Timothy P.L. RobertsH-Index: 102
Last. William P. DillonH-Index: 101
view all 6 authors...
Summary: A new CT perfusion technique providing extended anatomic coverage was evaluated in 12 patients with suspected acute middle cerebral artery ischemia. With a multidetector CT scanner, scans were obtained in an alternating fashion at two distinct ‘‘toggling’’ table positions (two 1-cm sections each) during a 40-mL contrast agent bolus (approximately 5 seconds per image), and perfusion parameter maps were created. The CT perfusion results were compared with follow-up images. Nine patients s...
#1James D. Eastwood (Duke University)H-Index: 29
#2James M. Provenzale (Duke University)H-Index: 98
Last. Ting-Yim Lee (Robarts Research Institute)H-Index: 34
view all 4 authors...
Previously reported methods of dynamic, contrast-enhanced, CT perfusion imaging in acute stroke have been promising but substantially limited by their dependence on very rapid rates of injection (typically 10–20 ml/s in an arm vein). Newly available deconvolution software permits the use of lower rates of injection (e. g., 3–4 ml/s), and rapidly provides maps of cerebral blood flow, cerebral blood volume and mean transit time. We report the potential of CT perfusion imaging performed with an inj...
Source
Cited By1
Newest
#1Michael A. Speidel (UW: University of Wisconsin-Madison)H-Index: 11
#2Brian P. WilfleyH-Index: 8
Last. Michael S. Van Lysel (UW: University of Wisconsin-Madison)H-Index: 11
view all 5 authors...
The scanning-beam digital x-ray (SBDX) system is designed for x-ray dose reduction in cardiac angiographic applications. Scatter reduction, efficient detection of primary x-rays, and an inverse beam geometry are the main components of the entrance dose reduction strategy. This paper reports the construction of an SBDX prototype, image reconstruction techniques, and measurements of spatial resolution and x-ray output. The x-ray source has a focal spot that is electronically scanned across a large...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.