Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
Abstract
We have engineered synthetic poly(ethylene glycol) (PEG)-based hydrogels as cell-ingrowth matrices for in situ bone regeneration. These networks contain a combination of pendant oligopeptide ligands for cell adhesion (RGDSP) and substrates for matrix metalloproteinase (MMP) as linkers between PEG chains. Primary human fibroblasts were shown to migrate within these matrices by integrin- and MMP-dependent mechanisms. Gels used to deliver...
Paper Details
Title
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
Published Date
Apr 21, 2003
Journal
Volume
21
Issue
5
Pages
513 - 518
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