MOUSE POPLITEAL LYMPH NODE ASSAY FOR ASSESSMENT OF ALLERGIC AND AUTOIMMUNITY-INDUCING POTENTIALS OF LOW-MOLECULAR-WEIGHT DRUGS
Abstract
In the present collaborative study, popliteal lymph node (PLN) responses to penicillin G (an allergenic chemical), D-penicillamine (an autoimmunity-inducing chemical), and barbital (a negative reference chemical) were investigated in three different mouse strains by ten pharmaceutical companies. Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25,...
Paper Details
Title
MOUSE POPLITEAL LYMPH NODE ASSAY FOR ASSESSMENT OF ALLERGIC AND AUTOIMMUNITY-INDUCING POTENTIALS OF LOW-MOLECULAR-WEIGHT DRUGS
Published Date
May 10, 1999
Volume
24
Issue
2
Pages
95 - 102
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