Original paper
Betulin-Derived Compounds as Inhibitors of Alphavirus Replication
Abstract
This paper describes inhibition of Semliki Forest virus (SFV) replication by synthetic derivatives of naturally occurring triterpenoid betulin (1). Chemical modifications were made to OH groups at C-3 and C-28 and to the C-20−C-29 double bond. A set of heterocyclic betulin derivatives was also assayed. A free or acetylated OH group at C-3 was identified as an important structural contributor for anti-SFV activity, 3,28-di-O-acetylbetulin (4)...
Paper Details
Title
Betulin-Derived Compounds as Inhibitors of Alphavirus Replication
Published Date
Oct 19, 2009
Journal
Volume
72
Issue
11
Pages
1917 - 1926