The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles

The overall objective of the present investigation was to demonstrate the effect of N-octyl-O-sulfate chitosan (NOSC) micelles on enhancing the oral absorption of paclitaxel (PTX) in vivo and in vitro, and identify the mechanism of this action of NOSC. In vivo, the oral bioavailability of PTX loaded in NOSC micelles (PTX-M) was 6-fold improved in comparison with that of an orally dosed Taxol®. In the Caco-2 uptake studies, NOSC micelles brought...