Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways

Gliptins have been recently shown to conquer neuronal degeneration in cell cultures via modulating glucagon‐like peptide ( GLP )‐1. This peptide produced in the gut not only crosses the blood–brain barrier but is also synthesized in the brain and acts on GLP ‐1R exerting central anti‐inflammatory and antiapoptotic effects, thus impeding neuronal damage. This study investigated the antiparkinsonian effect of vildagliptin, a dipeptidyl peptidase (...