Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Published on Sep 10, 2009in Nature42.778
· DOI :10.1038/NATURE08296
Michael R. Elliott51
Estimated H-index: 51
(Carter Center),
Faraaz B. Chekeni5
Estimated H-index: 5
(Carter Center)
+ 11 AuthorsKodi S. Ravichandran66
Estimated H-index: 66
(UVA: University of Virginia)
Sources
Abstract
The efficient removal of apoptotic cells in vivo is thought to be due to the release of 'find-me' signals by apoptotic cells that recruit motile phagocytes. Here, the caspase-dependent release of ATP and UTP during the early stages of apoptosis is demonstrated. ATP and UTP are found to act as chemoattractants in a process mediated through the ATP/UTP receptor P2Y2, which is present on monocytes and macrophages.
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