Platelet ITAM signaling is critical for vascular integrity in inflammation
Abstract
Platelets play a critical role in maintaining vascular integrity during inflammation, but little is known about the underlying molecular mechanisms. Here we report that platelet immunoreceptor tyrosine activation motif (ITAM) signaling, but not GPCR signaling, is critical for the prevention of inflammation-induced hemorrhage. To generate mice with partial or complete defects in these signaling pathways, we developed a protocol for adoptive...
Paper Details
Title
Platelet ITAM signaling is critical for vascular integrity in inflammation
Published Date
Jan 25, 2013
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