Statins, Cardiovascular Disease, and Drug Safety

Available for almost 2 decades, the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have emerged at the forefront of preventive drugs for cardiovascular disease because of a substantial clinical trial database demonstrating that statins reduce the risk for coronary artery disease morbidity and death across a broad range of at-risk patient cohorts. Although generally well tolerated, statins may be associated with...