Original paper
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
Abstract
Graft-versus-host disease (GVHD) is initiated after activation of donor T cells by host antigen-presenting cells (APCs). The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs and parenchymal cells and is further inducible by inflammation. We investigated whether lethal conditioning and GVHD induce IDO and if IDO prevents tissue injury by suppressing immune responses at the induction site. We determined that IDO is a...
Paper Details
Title
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
Published Date
Mar 15, 2008
Journal
Volume
111
Issue
6
Pages
3257 - 3265
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Notes
History