Original paper
MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis
Abstract
Type V collagen has been demonstrated to control fibril formation. The aim of this study was to develop an ELISA capable of detecting a fragment of type V collagen generated by MMP-2/9 and to evaluate the assay as biomarker for ankylosing spondylitis (AS). A fragment unique to type V collagen and generated by both MMP-2/9 cleaved at the amino acid position 1317 (C5M) was selected for ELISA development. 40 AS patients and 40 age-matched controls...
Paper Details
Title
MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis
Published Date
May 1, 2012
Journal
Volume
45
Issue
7-8
Pages
541 - 546
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Notes
History