Hypofractionated IMRT boost for prostate carcinoma with on-line targeting of the prostate gland: patient-specific PTV margins and acute toxicity results

Purpose/Objective: The objectives of this prospective phase 1 study were 1) to assess the feasibility of using patient specific PTV margins with daily on-line imaging of the prostate gland; and 2) to assess the toxicities of delivering a hypofractionated boost using IMRT to low and intermediate risk prostate cancer patients. Materials/Methods: Patients with histologically confirmed T1–T2, Gleason score ≤ 7, PSA ≤ 20 prostate carcinoma were...