Original paper
Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin
Abstract
We have in the present study explored the anticancer activity against human Burkitt's lymphoma cells (Ramos) of a series of small linear and cyclic tetrapeptides containing a β 2,2 ‐amino acid with either two 2‐naphthyl‐methylene or two para ‐CF 3 ‐benzyl side chains, along with their interaction with the main plasma protein human serum albumin (HSA). The cyclic and more amphipathic tetrapeptides revealed a notably higher anticancer potency...
Paper Details
Title
Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin
Published Date
Feb 6, 2014
Journal
Volume
20
Issue
4
Pages
279 - 291
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Notes
History