The rapid intermixing of cell surface antigens after formation of mouse human heterokaryons

Cells from established tissue culture lines of mouse (CIID) and human (VA-2) origin were fused together with Sendai virus, producing heterokaryons bearing both mouse and human surface antigens which were then followed by the indirect fluorescent antibody method. Within 40 min following fusion, total mixing of both parental antigens occurred in over 90 % of the heterokaryons. Mouse H-2 (histocompatibility) and human surface antigens were...