Risk of mortality on and off methadone substitution treatment in primary care: a national cohort study

To assess whether risk of death increases during periods of treatment transition, and investigate the impact of supervised methadone consumption on drug-related and all-cause mortality.National Irish cohort study.Primary care.A total of 6983 patients on a national methadone treatment register aged 16-65 years between 2004 and 2010.Drug-related (primary outcome) and all-cause (secondary outcome) mortality rates and rate ratios for periods on and...