Original paper

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

Volume: 65, Issue: 12, Pages: 3176 - 3185
Published: Nov 27, 2013
Abstract
Objective The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and purinergic receptor P2X 7 has been proposed to be upstream of NLRP3 activation. The aim of the present study, using murine models, was to investigate whether the P2X 7 /NLRP3 inflammasome pathway contributes to the pathogenesis of lupus nephritis (LN). Methods MRL/ lpr mice were treated with the selective P2X 7 antagonist brilliant blue G (BBG) for 8 weeks....
Paper Details
Title
P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
Published Date
Nov 27, 2013
Volume
65
Issue
12
Pages
3176 - 3185
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