A Randomized, Double-Blind, Placebo-Controlled Trial of Low Dose Imipramine for Treatment of Refractory Functional Dyspepsia (FD)

G A A b st ra ct s to assess dose response. Funnel plot analysis was performed to test for publication bias. Results: Systematic review identified 3,403 citations. Detailed evaluation identified 18 potentially relevant journal articles/abstracts, of which 5 fulfilled our inclusion criteria. Of the 1803 IBS patients randomized, 96% had non-constipated IBS. Meta-analysis of data from 5 studies demonstrated that rifaximin was superior to placebo...