Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage
Abstract
Kallikrein-binding protein (KBP) is a serine proteinase inhibitor (serpin). It specifically binds to tissue kallikrein and inhibits kallikrein activity. Our study was designed to test its effects on retinal neovascularization and vascular permeability.Endothelial cell proliferation was determined by [(3)H] thymidine incorporation assay and apoptosis quantified by Annexin V staining and flow cytometry. Effect on retinal neovascularization was...
Paper Details
Title
Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage
Published Date
May 1, 2003
Journal
Volume
46
Issue
5
Pages
689 - 698
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