G Gao
Medical University of South Carolina
AngiostatinVascular permeabilityDownregulation and upregulationEndocrinologyVascular endothelial growth factor AVascular endothelial growth factor BChemistryVascular endothelial growth factorRetinaNeovascularizationNerve growth factorAngiogenesisRetinalTissue kallikreinKringle domainCancer researchPEDFKallikreinBiologyCell biology
9Publications
5H-index
670Citations
Publications 8
Newest
#1G Gao (MUSC: Medical University of South Carolina)H-Index: 5
#2C. Shao (MUSC: Medical University of South Carolina)H-Index: 1
Last. J. X. Ma (MUSC: Medical University of South Carolina)H-Index: 8
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Aims/hypothesis Kallikrein-binding protein (KBP) is a serine proteinase inhibitor (serpin). It specifically binds to tissue kallikrein and inhibits kallikrein activity. Our study was designed to test its effects on retinal neovascularization and vascular permeability.
82 CitationsSource
#1RA Saunders (MUSC: Medical University of South Carolina)
#2G Gao (MUSC: Medical University of South Carolina)H-Index: 5
Last. J. X. Ma (MUSC: Medical University of South Carolina)H-Index: 8
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#1G GaoH-Index: 5
#2Yan LiH-Index: 4
Last. J. X. MaH-Index: 8
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#1J. X. Ma (MUSC: Medical University of South Carolina)H-Index: 8
#2G Gao (MUSC: Medical University of South Carolina)H-Index: 5
Last. Andrew C. Dudley (MUSC: Medical University of South Carolina)H-Index: 29
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#1G Gao (MUSC: Medical University of South Carolina)H-Index: 5
#2Yan Li (MUSC: Medical University of South Carolina)H-Index: 4
Last. Jian Xing Ma (MUSC: Medical University of South Carolina)H-Index: 73
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The present study compared susceptibilities of Sprague Dawley (SD) and Brown Norway (BN) rats with ischemia-induced retinal neovascularization. An exposure to constant hyperoxia followed by normoxia induced significant retinal neovascularization in BN rats but not in SD rats, as demonstrated by fluorescein retinal angiography, measurement of avascular area, and count of preretinal vascular cells. These results indicate a rat strain difference in susceptibility to retinal neovascularization. To u...
135 CitationsSource
#1G Gao (MUSC: Medical University of South Carolina)H-Index: 5
#2Yan Li (MUSC: Medical University of South Carolina)H-Index: 4
Last. Jian Xing Ma (MUSC: Medical University of South Carolina)H-Index: 73
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Abstract We have previously shown that intravitreal injection of plasminogen kringle 5 (K5), a potent angiogenic inhibitor, inhibits ischemia-induced retinal neovascularization in a rat model. Here we report that K5 down-regulates an endogenous angiogenic stimulator, vascular endothelial growth factor (VEGF) and up-regulates an angiogenic inhibitor, pigment epithelium-derived factor (PEDF) in a dose-dependent manner in vascular cells and in the retina. The regulation of VEGF and PEDF by K5 in th...
172 CitationsSource
#1D Zhang (MUSC: Medical University of South Carolina)H-Index: 2
#2P. L. Kaufman (MUSC: Medical University of South Carolina)H-Index: 1
Last. J. X. Ma (MUSC: Medical University of South Carolina)H-Index: 8
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Aims/hypothesis. Plasminogen kringle 5 is an endogenous angiogenic inhibitor. The purpose of the present study was to explore the potential application of kringle 5 in the treatment of retinal neovascularization. Methods. Plasminogen kringle 5 was expressed in E. coli and affinity-purified. Its anti-angiogenic activity was determined in cultured primary human capillary endothelial cells. Retinal neovascularization was induced in newborn rats by exposure to hyperoxia and then normoxia. Kringle 5 ...
109 CitationsSource
#1G Gao (MUSC: Medical University of South Carolina)H-Index: 5
#2Yan Li (MUSC: Medical University of South Carolina)H-Index: 4
Last. Jian Xing Ma (MUSC: Medical University of South Carolina)H-Index: 73
view all 6 authors...
Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-induced retinal neovascularization in rats. The retinas with neovascularization showed a 5-fold increase in VEGF while 2-fold decrease in PEDF, compared to the age-matched controls, resulting in an increased VEGF/PEDF ratio. The time course of the VEGF/PEDF ratio change correlated with the progression of retinal neovascu...
367 CitationsSource