Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis.

Published on Jan 1, 2016in Apoptosis4.543
· DOI :10.1007/S10495-015-1188-Z
Chong Zeng2
Estimated H-index: 2
(JNU: Jinan University),
Rui Xing1
Estimated H-index: 1
(THU: Tsinghua University)
+ 1 AuthorsFeiyue Xing12
Estimated H-index: 12
(JNU: Jinan University)
Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms.
📖 Papers frequently viewed together
65 Citations
#1Meijuan Zou (Nanjing Medical University)H-Index: 1
#2Chen Hu (CPU: China Pharmaceutical University)H-Index: 4
Last. Qinglong Guo (CPU: China Pharmaceutical University)H-Index: 61
view all 6 authors...
Autophagy is a tightly-regulated catabolic pathway involving degradation of cellular proteins, cytoplasm and organelles. Recent evidence suggests that autophagy plays a potential role in cell death as a tumor suppressor and that its induction especially in combination with apoptosis could be beneficial. It remains unclear if all cancer cells behave the same mechanism when autophagy is induced. Although mammalian target of rapamycin (mTOR) is well known as a negative regulator of autophagy, the r...
41 CitationsSource
#1Ralph Klose (DKFZ: German Cancer Research Center)H-Index: 8
#2Caroline Berger (DKFZ: German Cancer Research Center)H-Index: 2
Last. Andreas Fischer (DKFZ: German Cancer Research Center)H-Index: 27
view all 8 authors...
Aims Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain of the Notch ligands binds to the EGF-like repeats 11–13 of the Notch receptor. This study aimed to elucidate how soluble proteins containing these short domains interfere with Notch signalling duri...
16 CitationsSource
#1Mélissa Mathieu (UdeM: Université de Montréal)H-Index: 5
#2Frédéric Duval (UdeM: Université de Montréal)H-Index: 2
Last. Nathalie Labrecque (UdeM: Université de Montréal)H-Index: 24
view all 4 authors...
Following an infection, naive CD8 + T cells expand and differentiate into two main populations of effectors: short-lived effector cells (SLECs) and memory precursor effector cells (MPECs). There is limited understanding of the molecular mechanism and cellular processes governing this cell fate. Notch is a key regulator of cell fate decision relevant in many immunological pathways. In this study, we add to the role of Notch in cell fate decision and demonstrate that the Notch signaling pathway co...
30 CitationsSource
#1Selvi Kunnimalaiyaan (MCW: Medical College of Wisconsin)H-Index: 11
#2Kevin M. Sokolowski (MCW: Medical College of Wisconsin)H-Index: 6
Last. Muthusamy Kunnimalaiyaan (MCW: Medical College of Wisconsin)H-Index: 31
view all 5 authors...
Despite improvement in therapeutic strategies, median survival in advanced hepatocellular carcinoma (HCC) remains less than one year. Therefore, molecularly targeted compounds with less toxic profiles are needed. Xanthohumol (XN), a prenylated chalcone has been shown to have anti-proliferative effects in various cancers types in vitro. XN treatment in healthy mice and humans yielded favorable pharmacokinetics and bioavailability. Therefore, we determined to study the effects of XN and understand...
33 CitationsSource
#1Hyojin KimH-Index: 3
#2Lan Huang (IU: Indiana University)H-Index: 16
Last. Mervin C. Yoder (IU: Indiana University)H-Index: 92
view all 10 authors...
Background aims Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability. Because Notch signaling is critical for embryonic blood vessel formation in utero, we hypothesized that Notch pathway activation may enhance cultured ECFC vasculogenic properties in vivo.
22 CitationsSource
#1Soheila Sharghi-Namini (Singapore–MIT alliance)H-Index: 2
#2Evan Tan (Singapore–MIT alliance)H-Index: 3
Last. H. Harry Asada (MIT: Massachusetts Institute of Technology)H-Index: 71
view all 5 authors...
Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. However, whether Dll4-containing exosomes influence tip cells of existing capillaries is unknown. Using a 3D ...
64 CitationsSource
#1Roberta Ferraldeschi (The Royal Marsden NHS Foundation Trust)H-Index: 30
#2Daniel Nava Rodrigues (The Royal Marsden NHS Foundation Trust)H-Index: 33
Last. Johann S. de Bono (The Royal Marsden NHS Foundation Trust)H-Index: 124
view all 24 authors...
Background Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) occurs frequently in prostate cancers. Preclinical evidence suggests that activation of PI3K/AKT signaling through loss of PTEN can result in resistance to hormonal treatment in prostate cancer.
146 CitationsSource
#1Michele MilellaH-Index: 50
#2Italia FalconeH-Index: 11
Last. Ludovica CiuffredaH-Index: 21
view all 11 authors...
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor suppressor in a PI3K-independent manner. Indeed, the PTEN network regulates a broad spectrum of biological functions, modulating the flow of information from membrane-bound growth factor receptors to nuclear transcription factors, occurring in concert with other tumor suppressors and oncogenic signaling pathways. PTEN ac...
246 CitationsSource
#1Yuning Zhou (UK: University of Kentucky)H-Index: 17
#2Piotr G. Rychahou (UK: University of Kentucky)H-Index: 37
Last. B.M. Evers (UK: University of Kentucky)H-Index: 10
view all 5 authors...
The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Notch signaling is critical for the control of intestinal stem cell maintenance and differentiation. However, the precise mechanisms involved in the regulation of differentiation are not fully understood. Previously, we have shown that tuberous sclerosis 2 (TSC2) positively regulates the expression of the goblet cell differentiation marker, MUC2,...
45 CitationsSource
#1Yingying LinH-Index: 7
#2Weili ChenH-Index: 2
Last. Shuangyue XuH-Index: 4
view all 11 authors...
Dendritic cells (DCs) have the tolerogenic potential to regulate adaptive immunity and induce allografts acceptance. Here we investigated whether blockade of the CD40 pathway could enhance the immune tolerance induced by DC2.4 cells modified to express Jagged-1 (JAG1-DC) in heart transplantation. Results showed that JAG1-DC treatment combined with anti-CD40L monoclonal antibody (mAb) administration significantly prolonged cardiac allograft survival in mice, with long-term survival (>110 days) of...
15 CitationsSource
Cited By26
#1Yongfeng Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Zhiquan Yu (HUST: Huazhong University of Science and Technology)
Last. Huiping Zhang (HUST: Huazhong University of Science and Technology)H-Index: 7
view all 11 authors...
Mancozeb (MZ), an antibacterial pesticide, has been linked to reproductive toxicity, neurotoxicity, and endocrine disruption. However, whether MZ has cardiactoxicity is unclear. In this study, the cardiotoxic effects of exposure to environment-related MZ concentrations ranging from 1.88 μM to 7.52 μM were evaluated at the larval stage of zebrafish. Transcriptome sequencing predicted the mechanism of MZ-induced cardiac developmental toxicity in zebrafish by enrichment analysis of Kyoto Encycloped...
#1Kazutoshi Yamaguchi (Nagoya University)
#2Motoharu Hayashi (Nagoya University)H-Index: 5
Last. Kyosuke Takeshita (Saitama Medical University)H-Index: 31
view all 0 authors...
Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/-) mice provided with 12-week normal or high-fat diet. Haploinsufficiency of Notch1 was associated with adipose tissue accumulation despite similar food intake. White adipose tissue (WAT) of N1+/- showed accumulation of adipogenic cells (CD34+CD68+ cells), crown-like structures, and upregulation of cell proliferation...
#1Chong Zeng (Southern Medical University)H-Index: 1
Last. Dan Xiong (Southern Medical University)H-Index: 1
view all 8 authors...
BACKGROUND NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4+IL22+IFNγ-IL17A-) cells are a subgroup of CD4+ effector T cells that primarily generate IL-22. The regulatory mechanisms of the NOTCH signaling pathway involved in differentiation of the Th22 cell subset have not been completely elucidated. This study aimed to further explore the involvement of NOTCH signaling in Th...
#1Jiaxin Duan (NWAFU: Northwest A&F University)H-Index: 3
#2Huali Chen (SWUST: Southwest University of Science and Technology)
Last. Qingwang Li (NWAFU: Northwest A&F University)H-Index: 27
view all 10 authors...
Abstract Objectives Estrogen plays a critical role in the development and apoptosis of oocytes. Autophagy is an evolutionarily conserved and exquisitely regulated self-eating cellular process with important biological functions including the regulation of reproduction. This study aimed to determine the effect of autophagy regulated by the biologically active form of estrogen (17β-estradiol) in porcine oocyte maturation in vitro. Materials and methods We measured the effects of oocyte development...
1 CitationsSource
#1Waleska Kerllen Martins (USP: University of São Paulo)H-Index: 19
#2Renata A. BelottoH-Index: 2
Last. Tayana Mazin TsuboneH-Index: 10
view all 9 authors...
Cancer is an age-related disease that over the next 10 years will become the most prevalent health problem worldwide. Although cancer therapy has considerably improved in the last decades, novel treatment concepts are highly needed to defeat this disease. Photodynamic Therapy (PDT) highlights a promising avenue to cure and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT, however, there is a lack of ...
5 CitationsSource
Introduction: The aim of this study was to determine the role of Notch in indoxyl sulfate (IS)-induced vascular calcification (VC). Materials and methods: VC and expression of Notch-related and osteogenic molecules were examined in Dahl salt-sensitive (DS), DS hypertensive (DH), and DH IS-treated rats (DH+IS). The effects of IS on expression of Notch receptors, apoptotic activity, and calcification were examined in cultured aortic smooth muscle cells (SMCs). Results: Medial calcification was not...
1 CitationsSource
#1Kohei Nishino (Nagoya University)H-Index: 1
#2Seiji Watanabe (Nagoya University)H-Index: 14
Last. Koji Yamanaka (Nagoya University)H-Index: 41
view all 12 authors...
Intracellular mislocalization of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although the aggregation-prone, TDP-43 C-terminal domain is widely considered as a key component of TDP-43 pathology in ALS, recent studies including ours suggest that TDP-43 N-terminal fragments (TDP-∆C) may also contribute to the motor dysfunction in ALS. However, the specific pathological function...
6 CitationsSource
#1Chen Liu (ZJU: Zhejiang University)H-Index: 3
#2Xiawei Cheng (ZJU: Zhejiang University)H-Index: 4
Last. Weihua Gong (ZJU: Zhejiang University)H-Index: 4
view all 10 authors...
: Background and aims: Biological mechanisms that control liver regeneration remain poorly defined. However, these mechanisms are remarkable issues in the clinic that affect management of hepatic loss caused by liver surgery, traumatic injury, chronic infection, or liver poisoning. Increasing evidence has shown that various growth factors, cytokines, and metabolic signaling pathways affect the liver regenerative process. Our aim is to study the effect of bromodomain and extraterminal (BET) prote...
4 CitationsSource
#1Jinli Wang (SDU: Shandong University)H-Index: 1
#2Yuan Zheng (SDU: Shandong University)H-Index: 1
Last. Hongyang Zhao (SDU: Shandong University)H-Index: 1
view all 7 authors...
Epilepsy is characterized by recurrent unprovoked seizures and some seizures can cause neuronal apoptosis, which is possible to make contributions to the epilepsy phenotype, impairments in cognitive function or even epileptogenesis. Moreover, many studies have indicated that microRNA-34a (miRNA-34a) is involved in apoptosis through regulating Notch signaling. However, whether miRNA-34a participates in neuronal apoptosis after seizures remain unclear. Therefore, we aimed to explore the expression...
5 CitationsSource
#1Mohana Krishna Gopisetty (University of Szeged)H-Index: 4
#2Dávid Kovács (University of Szeged)H-Index: 10
Last. Mónika Kiricsi (University of Szeged)H-Index: 13
view all 11 authors...
Background Development of multidrug resistance (MDR) is a major burden of successful chemotherapy, therefore, novel approaches to defeat MDR are imperative. Although the remarkable anti-cancer propensity of silver nanoparticles (AgNP) has been demonstrated and their potential application in MDR cancer has been proposed, the nanoparticle size-dependent cellular events directing P-glycoprotein (Pgp) expression and activity in MDR cancer have never been addressed. Hence, in the present study we exa...
19 CitationsSource