Yeast as a simple eukaryotic model to study human diseases linked to membrane trafficking

Many human diseases are linked to mutations in genes encoding membrane trafficking proteins, among them the X-linked centronuclear myopathy (XLCNM) and ciliopathies. We use yeast Saccharomyces cerevisiae as a model system to study these human disease trafficking genes. It is a good model because yeast and human cells present similar intracellular organization and its membrane trafficking and metabolism are well characterized. We first studied...