Review paper
Clinical consequences of circulating CD28-negative T cells for solid organ transplantation
Abstract
CD28 is an important costimulatory molecule expressed on T cells, interacting with CD80 and CD86 on antigen-presenting cells. All naïve T cells express CD28, but memory T cells may become CD28 negative (CD28neg) as a result of repetitive cell divisions, the influence of TNF-alpha, and infection with cytomegalovirus. This results in accumulation of CD28neg T cells, which may constitute >50% of the total circulating T-cell population in the...
Paper Details
Title
Clinical consequences of circulating CD28-negative T cells for solid organ transplantation
Published Date
Sep 8, 2015
Journal
Volume
29
Issue
3
Pages
274 - 284
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Notes
History