MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia
Abstract
Key Points Genetic or pharmacologic inhibition of MEK4 and MEK2 enhances prednisolone-induced cell death in ALL models. MAPK signaling cascades are activated at relapse compared to diagnosis in ALL samples and have enhanced response to MEK...
Paper Details
Title
MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia
Published Date
Nov 5, 2015
Journal
Volume
126
Issue
19
Pages
2202 - 2212
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Notes
History