Radiotherapy and corticosteroids for preventing and treating keloid scars

Published on Apr 27, 2017in Cochrane Database of Systematic Reviews9.289
· DOI :10.1002/14651858.CD010883.PUB2
Patricia L Danielsen7
Estimated H-index: 7
(UWA: University of Western Australia),
Wang Ru1
Estimated H-index: 1
(Boston Children's Hospital)
+ 5 AuthorsYing Cen1
Estimated H-index: 1
(Sichuan University)
Sources
Abstract
Reason for withdrawal from publication This protocol has been withdrawn as authors were unable to progress the review.
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References56
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#1Michael H. TirganH-Index: 2
#2Christopher M. Shutty (Staten Island University Hospital)H-Index: 2
Last. Tae Hwan Park (SKKU: Sungkyunkwan University)H-Index: 1
view all 3 authors...
Keloid disorder (KD) is a fibroproliferative ailment of the cutaneous connective tissue secondary to dysregulation in various skin repair and healing processes. This disorder is characterized by excess collagen and/or glycoprotein depositions in the dermis. Age of onset of KD is not well documented. Based on clinical observations, various authors have reported the onset of KD to be between the ages of 10 and 30 years. We report on an African American female who developed bilateral auricular kelo...
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#1Parit A. Patel (UC: University of Cincinnati)H-Index: 8
#2J K Bailey (UC: University of Cincinnati)H-Index: 4
Last. Kevin P. Yakuboff (UC: University of Cincinnati)H-Index: 16
view all 3 authors...
Abstract Introduction Keloids scars are challenging problems facing many reconstructive surgeons and have proven to be resistant to many treatments. This is evident by the broad range of treatments available and implemented with inconsistent results. We reviewed our experience to better define the disorder and to evaluate the impact of specific treatment options as related to our patient population. Methods After obtaining Institutional Review Board approval, we examined the medical records of p...
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Background:Keloid scars cause pain, itching, functional limitation, and disfigurement, leading to psychological distress. Progress in treatment regimens is hindered by the lack of a universally accepted outcome measure. The Patient and Observer Scar Assessment Scale is a tool for the assessment of s
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Cellular senescence, being the result of serial subculturing or of exogenous stresses, is considered to be a potent anticancer mechanism. However, it has been proposed that senescent cells may enhance the growth of adjacent malignant epithelial cells. On the other hand, exposure of tumors to repeated low doses of γ-irradiation is a common treatment regime. Nevertheless, γ-irradiation also affects the neighboring stromal cells and the interaction of the latter with cancer cells. Accordingly, in t...
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#1Satoko YamawakiH-Index: 10
#2Motoko NaitohH-Index: 14
Last. Shigehiko SuzukiH-Index: 40
view all 5 authors...
Abstract:We have treated keloids using a combination of surgical excision and postoperative irradiation. The objective of this study was to evaluate the results of our treatment over 12 years. From 1995 until 2006, we treated keloids using the aforementioned treatment. If we identified a sign of rec
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#1Jian-Sheng Diao (Fourth Military Medical University)H-Index: 8
#2Wen-Sen Xia (Fourth Military Medical University)H-Index: 6
Last. Xu-De Sun (Fourth Military Medical University)H-Index: 1
view all 9 authors...
Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF)-β1 is well known as the crucial fibrogenic cytokine promoting ECM production and tissue fibrosis in keloid forming. Epigenetic modifications have been shown to play a role in the pathogenesis of cancer as well as autoimmune and inflammatory disorders. Recent publication reports epigenetic modifica...
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#1Sebastiano Recalcati (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 10
#2Massimo Caccialanza (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 16
Last. Roberta Piccinno (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 18
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Abstract Background: Auricular keloids are very frequent and often have a peculiar response to therapy. Despite a variety of treatment options, recurrence is the norm. An integrated surgical–radiotherapy approach is suggested to have the most significant effect on recurrence rate, varying from 3.5% to 27%. The aim of this study was to assess, through a retrospective review of our cases, the effectiveness and safety of postoperative radiotherapy performed over 26 years and to observe whether all ...
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#1Denise O'ConnorH-Index: 1
Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any Insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient’s quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therape...
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#1Matthias EggerH-Index: 166
#2David MoherH-Index: 136
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