The influence of amino acids on aztreonam spray-dried powders for inhalation

Published on Dec 1, 2015in Asian Journal of Pharmaceutical Sciences6.598
· DOI :10.1016/J.AJPS.2015.08.002
Xiao-Fei Yang2
Estimated H-index: 2
(Soochow University (Suzhou)),
Ying Xu29
Estimated H-index: 29
(Soochow University (Suzhou))
+ 1 AuthorsHao-Ying Li2
Estimated H-index: 2
Sources
Abstract
Abstract The dry powder inhalation of antibiotics for the treatment of lung infections has attracted drastically increasing attention as it offers rapid local therapy at lower doses and minimal side effects. In this study, aztreonam (AZT) was used as the model antibiotic and spray-dried to prepare powders for inhalation. Amino acids of glycine (GLY), histidine (HIS) and leucine (LEU) were used as excipients to modify the spray-dried particles. It was demonstrated that the GLY-AZT spray-dried powders formed huge agglomerates with the size of 144.51 µm, which made it very difficult to be delivered to the lungs (FPF: 0.29% w/w only). In comparison with the AZT spray-dried powders, HIS-modified spray-dried powders showed increased compressibility, indicating larger distance and less cohesion between particles; while the LEU-modified spray-dried particles showed a hollow structure with significantly decreased densities. The fine particle fraction for HIS- and LEU-modified powders was 51.4% w/w and 61.7% w/w, respectively, and both were significantly increased (one-way ANOVA, Duncan's test, P  0.05) compared to that of AZT spray-dried powders (45.4% w/w), showing a great potential to be applied in clinic.
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Abstract Respiratory infections represent a major global health problem. They are often treated by parenteral administrations of antimicrobials. Unfortunately, systemic therapies of high-dose antimicrobials can lead to severe adverse effects and this calls for a need to develop inhaled formulations that enable targeted drug delivery to the airways with minimal systemic drug exposure. Recent technological advances facilitate the development of inhaled anti-microbial therapies. The newer mesh nebu...
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