Asian Journal of Pharmaceutical Sciences
Papers 707
1 page of 71 pages (707 results)
Abstract null null Spinal cord injury (SCI) causes Ca2+ overload, which can lead to inflammation and neuronal apoptosis. In this study, we prepared a nanovesicle derived from macrophage membrane (MVs), which encapsulated sodium alginate (SA) and naloxone (NAL) to inhibit inflammation and protect neurons by reducing the free Ca2+ concentration at the SCI site. Based on the transmission electron microscopy (TEM) image, the encapsulated sample (NAL–SA–MVs) had a particle size of approximately 134 ±...
#1Peng Liu (CSU: Central South University)H-Index: 11
#2Ying Peng (CSU: Central South University)H-Index: 5
Last. Wenhu Zhou (CSU: Central South University)H-Index: 20
view all 4 authors...
Abstract null null Chemodynamic therapy (CDT) is considered as a promising modality for selective cancer therapy, which is realized via Fenton reaction-mediated decomposition of endogenous H2O2 to produce toxic hydroxyl radical (•OH) for tumor ablation. While extensive efforts have been made to develop CDT-based therapeutics, their in vivo efficacy is usually unsatisfactory due to poor catalytic activity limited by tumor microenvironment, such as anti-oxidative systems, insufficient H2O2, and mi...
#1Anpu Yang (PKU: Peking University)H-Index: 1
#2Yanan Sun (PKU: Peking University)H-Index: 2
Last. Qiang Zhang (PKU: Peking University)H-Index: 89
view all 13 authors...
Abstract null null Photothermal (PTT) and photodynamic (PDT) combined therapy has been hindered to clinical translation, due to the lack of available biomaterials, difficult designs of functions, and complex chemical synthetic or preparation procedures. To actualize a high-efficiency combination therapy for cancer via a feasible approach, three readily available materials are simply associated together in one-pot, namely the single-walled carbon nanohorns (SWCNH), zinc phthalocyanine (ZnPc), and...
#1Jiafu Mu (ZJU: Zhejiang University)H-Index: 3
#2Jiahe Wu (ZJU: Zhejiang University)H-Index: 12
Last. Jian-Qing Gao (ZJU: Zhejiang University)H-Index: 41
view all 7 authors...
Abstract null null Traumatic spinal cord injury is a fatal acute event without effective clinical therapies. Following the trauma, immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair, where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes. Effective emergency strategies are required to be convenient, biocompatible, and stable. Herein,...
#1Li Jingjing (CPU: China Pharmaceutical University)H-Index: 1
#2Kai Zhang (CPU: China Pharmaceutical University)
Last. Lifang Yin (CPU: China Pharmaceutical University)H-Index: 27
view all 11 authors...
Strong infectivity enables coronavirus disease 2019 (COVID-19) to rage throughout the world. Moreover, the lack of drugs with definite therapeutic effects further aggravates the spread of the pandemic. Remdesivir is one of the most promising anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drugs. However, the limited clinical effects make its therapeutic effect controversial, which may result from the poor accumulation and activation of remdesivir in the lung. Therefore, we deve...
#1Zijun Jiang (CPU: China Pharmaceutical University)H-Index: 1
#2Tianyi Li (CPU: China Pharmaceutical University)
Last. Yang Ding (CPU: China Pharmaceutical University)H-Index: 17
view all 8 authors...
Abstract null null The booming photothermal therapy (PTT) has achieved great progress in non-invasive oncotherapy, and paves a novel way for clinical oncotherapy. Of note, mild temperature PTT (mPTT) of 42–45 °C could avoid treatment bottleneck of the traditional PTT, including nonspecific injury to normal tissues, vasculature and host antitumor immunity. However, cancer cells can resist mPTT via heat shock response and autophagy, thus leading to insufficient mPTT monotherapy to ablate tumor. To...
#1Akhilesh DubeyH-Index: 8
Last. Sally A. El-Zahaby (Pharos University in Alexandria)H-Index: 8
view all 6 authors...
The spread of SARS-CoV-2 as an emerging novel coronavirus disease (COVID-19) had progressed as a worldwide pandemic since the end of 2019. COVID-19 affects firstly lungs tissues which are known for their very slow regeneration. Afterwards, enormous cytokine stimulation occurs in the infected cells immediately after a lung infection which necessitates good management to save patients. Exosomes are extracellular vesicles of nanometric size released by reticulocytes on maturation and are known to m...
#1Na Xu (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Ranran Guo (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Peng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 17
view all 6 authors...
Abstract null null Exosomes are vesicles secreted by a variety of living cells, containing proteins, RNA and other components, which are nanoscale capsules commonly existed in the body. Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells, which can play multiple roles in tumor treatment. On the one hand, exosomes can be used as carriers and biomarkers, participate in the apoptosis signaling pat...
#1Shanshan Xu (Sichuan University)H-Index: 5
Last. Qin He (Sichuan University)H-Index: 49
view all 9 authors...
Abstract null null Metastasis is closely related to the high mortality of cancer patients, which is regulated by multiple signaling pathways. Hence, multiphase blocking of this biological process is beneficial for cancer treatments. Herein, we establish a multifunctional self-delivering system by synthesizing D-α-tocopheryl succinates (TOS)-conjugated chondroitin sulfate (CS) (CT NPs), which both serve as nanocarrier and antimetastatic agent that affects different phases of the metastatic cascad...
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