Original paper

Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity

Volume: 21, Issue: 17, Pages: 6480 - 6491
Published: Sep 1, 2001
Abstract
Glia undergo inflammatory activation in most CNS pathologies and are capable of killing cocultured neurons. We investigated the mechanisms of this inflammatory neurodegeneration using a mixed culture of neurons, microglia, and astrocytes, either when the astrocytes were activated directly with lipopolysaccharide (LPS) and interferon-γ (IFN-γ) or LPS/IFN-γ-activated microglia were added to mixed neuronal cultures. In either case, activated glia...
Paper Details
Title
Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity
Published Date
Sep 1, 2001
Volume
21
Issue
17
Pages
6480 - 6491
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