Activation of PAR₂ receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint

Background and Purpose The PAR 2 receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR 2 activation in the rat knee joint. Experimental Approach PAR 2 in rat knee joint dorsal root ganglia ( DRG ) cells at L 3‐ L 5, retrogradely labelled with Fluoro‐gold ( FG ) were demonstrated immunohistochemically. Electrophysiological recordings from knee joint nerve fibres in urethane anaesthetized Wistar...