Original paper
Abstract W P352: Clopidogrel-Statin Interaction in Secondary Prevention After Ischemic Stroke: A Randomized Double Blind Placebo Controlled Crossover Study
Abstract
BACKGROUND: In secondary prevention after ischemic stroke variability in individual responsiveness to clopidogrel is a clinically relevant problem. Among possible mechanisms that may contribute to this phenomenon, clopidogrel-statin interactions are discussed. Particularly, competitive metabolization of lipohilic statins (i.e. simvastatin) and clopidogrel by cytochrome P450 (CYP) 3A4 was suggested to reduce the inhibitory effect of clopidogrel...
Paper Details
Title
Abstract W P352: Clopidogrel-Statin Interaction in Secondary Prevention After Ischemic Stroke: A Randomized Double Blind Placebo Controlled Crossover Study
Published Date
Feb 1, 2014
Journal
Volume
45
Issue
suppl_1
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Notes
History