The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Volume: 172, Issue: 3, Pages: 490 - 499
Published: Apr 18, 2013
Abstract
Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we investigated the effect of commonly used chemotherapeutic drugs dexamethasone, doxorubicin, cisplatin and irinotecan and glucocorticoids on monocyte-derived DCs (moDCs). Dexamethasone displayed the strongest inhibitory effect on DC differentiation. The...
Paper Details
Title
The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Published Date
Apr 18, 2013
Volume
172
Issue
3
Pages
490 - 499
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