Clinical and Experimental Immunology
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#1Sandra Amor (VUMC: Vanderbilt University Medical Center)H-Index: 44
#2Erik Nutma (VUMC: Vanderbilt University Medical Center)H-Index: 9
Last. David R. Owen (Imperial College London)H-Index: 63
view all 3 authors...
Innate and adaptive immune responses in the central nervous system (CNS) play critical roles in the pathogenesis of neurological diseases. In the first of a two-part special issue, leading researchers discuss how imaging modalities are used to monitor immune responses in several neurodegenerative diseases and glioblastoma and brain metastases. While comparative studies in humans between imaging and pathology are biased towards the end stage of disease, animal models can inform regarding how immu...
#1Alex Wonnaparhown (Duke University)
#2Alexandra Stefanovic (Duke University)H-Index: 11
Last. Haley P. Hostetler (Duke University)H-Index: 1
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Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is rare and is associated with underlying lymphoproliferative diseases. C1-INH deficiency may be due to neoplastic over-consumption of C1-INH and the generation of anti-C1-INH autoantibodies. Uncovering an occult malignancy can lead to earlier oncology referral and improvement of angioedema after treatment of the underlying lymphoproliferative disorder. We characterized seven patients with C1-INH-AAE that highlights the imp...
#1Gabriel OsbornH-Index: 4
#2Chara StavrakaH-Index: 12
Last. Sophia N. KaragiannisH-Index: 36
view all 12 authors...
#1Luciano Fraga (UFRGS: Federal University of Rio Grande do Sul)H-Index: 17
#2Isadora D’Ávila Tassinari (UFRGS: Federal University of Rio Grande do Sul)H-Index: 3
Last. Victorio Bambini-Junior (UCLan: University of Central Lancashire)H-Index: 1
view all 5 authors...
Since the first studies of the nervous system by the Nobel laureates Camillo Golgi and Santiago Ramon y Cajal using simple dyes and conventional light microscopes, microscopy has come a long way to the most recent techniques that make it possible to perform images in live cells and animals in health and disease. Many pathological conditions of the central nervous system have already been linked to inflammatory responses. In this scenario, several available markers and techniques can help imaging...
#1Rafael Roesler (UFRGS: Federal University of Rio Grande do Sul)H-Index: 44
#2Simone Afonso DiniH-Index: 1
Last. Gustavo R Isolan (Mackenzie Investments)H-Index: 1
view all 3 authors...
Brain tumors and brain metastases induce changes in brain tissue remodelling that lead to immunosuppression and trigger an inflammatory response within the tumor microenvironment. These immune and inflammatory changes can influence invasion and metastasis. Other neuroinflammatory and necrotic lesions may occur in patients with brain cancer or brain metastases as sequelae from treatment with radiotherapy. Glioblastoma (GBM) is the most aggressive primary malignant brain cancer in adults. Imaging ...
#1Yawei Tang (Dalian Medical University)H-Index: 9
#2Ziran Bai (Dalian Medical University)
Last. Xia Li (Dalian Medical University)H-Index: 23
view all 10 authors...
B cell dysfunction and inflammatory cytokine over-production participate in the pathogenesis of rheumatoid arthritis (RA). Here we compared peripheral B cell homeostasis and immune functions between RA patients and healthy controls (HC) and explored vital signaling pathways involved in altered RA B cells. We found that RA patients showed significantly decreased frequencies of peripheral CD19+ CD27+ CD24high regulatory B (Breg) cells but increased frequencies of CD19+ CD27+ CD38high plasmablasts ...
#1Carlos MartinezH-Index: 30
Last. Sheryl van Nunen (USYD: University of Sydney)H-Index: 6
view all 3 authors...
This large cohort study from the US Premier Healthcare Database evaluated the risk and predictors of anaphylaxis in association with intravenous immunoglobulin (IvIg) therapy in the inpatient and outpatient setting. Data were collected retrospectively (January 2009-December 2018) from 24 919 patients administered IgPro10 IvIg, median age 54 years. Immunoglobulins of interest were IgPro10 and other IvIg given before or after IgPro10. Moderate and severe anaphylaxis was identified from same-day pa...
#1Alessandra Bettiol (University of Florence)H-Index: 16
#2Matteo Becatti (University of Florence)H-Index: 30
Last. Danilo Malandrino (University of Florence)H-Index: 5
view all 15 authors...
Behcet's syndrome (BS) is a systemic vasculitis with several clinical manifestations. Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive oxygen species (ROS) production and neutrophil extracellular traps (NETs) release. Here, we investigated neutrophil-mediated mechanisms of damage in non-vascular BS manifestations and explored the in-vitro effects of colchicine in counteracting these mechanisms. NETs and intracellular ROS production was assessed in blood s...
#1Jiantao Han (WHU: Wuhan University)
#2Chao Ke (WHU: Wuhan University)H-Index: 1
Last. Xingwang Xie (WHU: Wuhan University)H-Index: 1
view all 6 authors...
Hepatocellular carcinoma (HCC) is the world's leading cause of tumor-related mortalities. Natural killer (NK) cells play a critical role at the first immunological defense line against HCC initiation and progression. NK cell dysfunction is therefore an important mechanism for immune evasion of HCC cells. In the present study using a murine HCC model, we revealed the down-regulation of PR/SET Domain 10 (PRDM10) in hepatic NK cells that were phenotypically and functionally exhausted. PRDM10 silenc...
#1Motoshi Sonoda (Kyushu University)H-Index: 5
#2Masataka Ishimura (Kyushu University)H-Index: 14
Last. Shouichi Ohga (Kyushu University)H-Index: 37
view all 9 authors...
Mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1)-deficiency is a rare combined immunodeficiency characterized by recurrent infections, dermatitis and enteropathy. We herein investigate the immunological profiles of our patient and previously reported children with MALT1-deficiency. A mutation analysis was performed by targeted panel sequencing for primary immunodeficiency. Lymphocyte subset, activation and B cell differentiation were analyzed by flow cytometry and t-distri...
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