#1Yuan Wu(HUST: Huazhong University of Science and Technology)H-Index: 3
#2Yue Gao(HUST: Huazhong University of Science and Technology)H-Index: 6
Last. Qingqing Mo(HUST: Huazhong University of Science and Technology)H-Index: 6
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The recurrence of patients with epithelial ovarian cancer (EOC) is largely attributed to tumour cells escaping from the surveillance of immune cells. However, to date there is a lack of studies that have systematically evaluated the associations between the infiltration fraction of immune cells and the recurrence risk of EOC. Based on the micro-ribonucleic acid (microRNA) expression profiles of 441 EOC patients, we constructed a microRNA-based panel with recurrence prediction potential using non...
#2A Lu(MDC: Max Delbrück Center for Molecular Medicine)
Last. Claudia Chien(MDC: Max Delbrück Center for Molecular Medicine)H-Index: 8
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Myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal...
#1Simon Lea(MAHSC: Manchester Academic Health Science Centre)H-Index: 15
#2Rosemary Gaskell(MAHSC: Manchester Academic Health Science Centre)H-Index: 1
Last. Dave Singh(University of Manchester)H-Index: 75
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Defective phagocytosis has been shown in COPD bronchoalveolar lavage and blood monocyte derived macrophages. Phagocytic capabilities of sputum macrophages and neutrophils in COPD are unknown. We investigated phagocytosis in these cells from COPD patients and controls. Phagocytosis of Streptococcus pneumoniae or fluorescently labelled non-typeable Haemophilus influenzae (NTHi) by sputum macrophages and neutrophils was determined by gentamycin protection assay (COPD; n=5) or flow cytometry in 14 C...
Guillain-Barre' syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of peripheral nervous system (PNS). Macrophages play a central role in its animal model, experimental autoimmune neuritis (EAN), which has been well-accepted. Additionally, NF-κB inhibitors has been used to treat cancers and showed beneficial effects. Here we investigated the therapeutic effect of M2 macrophage and NF-κB pathway's correlation with macrophages activation in EAN in C57BL/6 mice. We de...
Last. Raz Somech(TAU: Tel Aviv University)H-Index: 27
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Signal transducer and activator of transcription (STAT)1 heterozygous gain-of-function (GOF) mutations are known to induce immune dysregulation and chronic mucocutaneous candidiasis (CMCC). Previous reports suggest an association between demodicosis and STAT1 GOF. However, immune characterization of these patients is lacking. Here, we present a retrospective analysis of patients with immune dysregulation and STAT1 GOF who presented with facial and ocular demodicosis. In-depth immune phenotyping ...
Last. Yuekang Xu(Anhui Normal University)H-Index: 19
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Atherosclerosis is an inflammatory disease with break-down of homeostatic immune regulation of vascular tissues. As critical initiator of host immunity, dendritic cells (DCs) have been identified in the aorta of healthy individuals and atherosclerotic patients as well, whose roles in regulating the arterial inflammation aroused great interests. Accumulating evidences have now pointed to the fundamental roles for DCs in every developmental stages of atherosclerosis due to their myriads of functio...
Last. Fabrizio Conti(Sapienza University of Rome)H-Index: 54
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Antiphospholipid syndrome (APS) is a systemic autoimmune disorder defined by the simultaneous presence of vascular clinical events, pregnancy morbidity and antiphospholipid antibodies (aPL). In clinical practice it is possible to find patients with APS who are persistently negative for the routine aPL tests ("seronegative APS", SN-APS). Recently, the identification of aPL IgA and/or anti-β2-GPI IgA was shown to represent a further test in SN-APS patients. In this study we analyzed the presence o...
Last. Elena Bargagli(UNISI: University of Siena)H-Index: 30
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Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Recent research has focused on the role of autoimmunity in its development and progression. This study aimed to determine and define disturbance and distribution of T- and B-cell subsets in the alveolar and peripheral compartments. Thirteen patients were selected for the study (median age (IQR), 57 years (48-59); 23% were males). Twelve healthy controls (median age (IQR) 53 years (52-65); 16% males) were also enrolled in the...
Chronic hepatitis B infection remains a serious global health threat, contributing to large numbers of deaths through liver cirrhosis and hepatocellular carcinoma. Current treatment does not eradicate disease and therefore new treatments are urgently needed. In acute HBV a strong immune response is necessary to clear the virus, but in chronic infection the immune response is weakened and dysfunctional. Therapeutic vaccination describes the process of inoculating individuals with a non-infective ...
Four cases of idiopathic multicentric Castleman disease (iMCD) reportedly have variants in hereditary autoinflammatory disease-related genes; however, the frequency and role of these variants in iMCD is still unknown. We therefore investigated such gene variants among patients with iMCD and aimed to reveal the relationship between iMCD and autoinflammatory disease-related genes. We reviewed 14 Japanese iMCD patients who were recruited between January 2015 and September 2019. All patients met bot...