Macrophage very low density lipoprotein receptor regulates adipose tissue inflammation in obesity

Adipose tissue macrophages (ATMs) are key players to balance pro- and anti-inflammatory responses in fat tissues. In obesity, increased ATMs have been implicated in pro-inflammatory responses and lipid dysregulation. However, underlying mechanisms of lipid accumulation in ATMs of obese animals and their roles are largely unknown. In this study, we demonstrated that elevated expression of very low density lipoprotein receptor (VLDLR) could...