Antimicrobial Agents and Chemotherapy
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#1Bridgette M. Cumming (UKZN : University of KwaZulu-Natal)H-Index: 12
#2Baig Z (UKZN : University of KwaZulu-Natal)
Last. Adrie J. C. Steyn (UAB: University of Alabama at Birmingham)H-Index: 29
view all 5 authors...
Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following: (i) to identify the pharmacokinetic-pharmacodynamic (PK-PD) index associated with the efficacy of gepotidacin against E. coli; (ii) to determine the magnitude of the above-described PK-PD index associated with various bacterial reduction endpo...
#1Jared L. CrandonH-Index: 28
#2Joseph L. KutiH-Index: 57
Last. David P. Nicolau (Hartford Hospital)H-Index: 76
view all 3 authors...
#1Lina M Rivas (UDD: Universidad del Desarrollo)H-Index: 5
#2Manuel Alcalde‐Rico (Pontifical Catholic University of Valparaíso)H-Index: 1
Last. Jose M. Munita (UDD: Universidad del Desarrollo)H-Index: 26
view all 12 authors...
Ceftolozane/tazbactam (C/T) is a potent anti-pseudomonal agent that has clinical utility against infections caused by non-carbapenemase producing carbapenem-resistant P. aeruginosa (non-CP-CR-PA). Accurate, precise and reliable antimicrobial susceptibility testing (AST) is crucial to guide clinical decisions. However, studies assessing the performance of different AST methods against non-CP-CR-PA- (the main clinical niche for C/T), are lacking. Here, we evaluated performance of gradient strips (...
#1Masakazu Niimi (University of Otago)H-Index: 11
#2Kyoko Niimi (University of Otago)H-Index: 20
Last. Erwin Lamping (University of Otago)H-Index: 16
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Overexpression of ATP-binding cassette (ABC) transporters is a major cause of drug resistance in fungal pathogens. Milbemycins, enniatin B, beauvericin and FK506 are promising leads for broad-spectrum fungal multidrug efflux pump inhibitors. The characterization of naturally generated inhibitor resistant mutants is a powerful tool to elucidate structure-activity relationships in ABC transporters. We isolated twenty Saccharomyces cerevisiae mutants overexpressing Candida albicans ABC pump Cdr1 va...
#1Minh-Duy Phan (UQ: University of Queensland)H-Index: 29
#2Kate M. Peters (UQ: University of Queensland)H-Index: 22
Last. Mark A. Schembri (UQ: University of Queensland)H-Index: 77
view all 12 authors...
Escherichia coli ST131 is a recently emerged antibiotic resistant clone responsible for high rates of urinary tract and bloodstream infections. Despite its global dominance, the precise mechanisms that have driven the rapid dissemination of ST131 remain unknown. Here, we show that the plasmid-associated resistance gene encoding the AAC(6')-Ib-cr enzyme that inactivates the fluoroquinolone antibiotic ciprofloxacin is present in >70% of strains from the most rapidly expanding subgroup of multidrug...
#1Grace Akrong (University of Poitiers)
#2Alexia Chauzy (University of Poitiers)H-Index: 3
Last. Sandrine Marchand (University of Poitiers)H-Index: 23
view all 9 authors...
The inoculum effect (i.e., reduction in antimicrobial activity at large starting inoculum) is a phenomenon described for various pathogens. Since limited data exist regarding inoculum effect of Acinetobacter baumannii, we evaluated killing of A. baumannii by polymyxin B, a last-resort antibiotic, at several starting inocula and developed a PKPD model to capture this phenomenon. In vitro static time-kill experiments were performed using polymyxin B at concentrations ranging from 0.125 to 128 mg/L...
#1Dipti Sharma (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 3
#2Raees A. Paul (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 6
Last. Arunaloke Chakrabarti (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 65
view all 15 authors...
Objectives: Echinocandins are frontline antifungal agents in the management of invasive infections due to multi-drug resistant Candida auris. The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection. Methods: A total of 199 C. auris isolates originating from thirty centres across India were tested for susceptibility to echino...
There are few reports on the clinical course of proven invasive aspergillosis (IA) due to rare/cryptic species in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. We retrospectively reviewed the electronic medical records of patients who underwent allo-HSCT between January 2012 and December 2018. Of 934 allo-HSCT recipients, 10 were diagnosed with proven IA and 61 were diagnosed with probable IA. DNA sequencing was performed in cases of proven IA, and Aspergillus could be id...
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