#1Qi Ding(MSU: Michigan State University)H-Index: 13
#2Xueting Wu(CAS: Chinese Academy of Sciences)H-Index: 6
Last. Hongbing Wang(MSU: Michigan State University)H-Index: 34
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Background null Fragile X syndrome (FXS) is caused by mutations in the FMR1 gene. It is a form of heritable intellectual disability and autism. Despite recent advance in elucidating disease mechanisms, there is no efficacious medication. As de novo drug development is a lengthy process, repurposing the existing FDA-approved drugs offers an opportunity to advance clinical intervention for FXS. Our previous study with transcriptome analysis predicts potential therapeutic effects of vorinostat on F...
#1Manish K. Jha(The University of Texas Southwestern Medical Center)H-Index: 20
There is a large unmet need for effective treatment of major depressive disorder (MDD), an often chronic/recurrent disorder that affects 1 in 5 adults during their lifetime in the United States. Clinicians and individuals with MDD often rely on augmentation approaches given the low rate of remission with the initial antidepressant treatment. Therefore, the report by Savitz and colleagues on the safety and efficacy of seltorexant is of great interest as it provides initial evidence for the antide...
BACKGROUND Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders marked by a lack of social interaction, restrictive interests and repetitive behaviors. There is a paucity of pharmacological treatments to reduce core ASD symptoms. Various lines of evidence indicate that reduced brain muscarinic cholinergic receptor activity may contribute to an ASD phenotype. METHODS The present experiments examined whether the partial M1 muscarinic receptor agonist, CDD-0102A, alleviates beh...
Background null Astrocytes and microglia are involved in the pathophysiology of epilepsy and bipolar disorder with a link to inflammation. We aimed to investigate the effects of the antiepileptic and mood-stabilizing drugs lamotrigine (LTG) and topiramate (TPM) on glial viability, microglial activation, cytokine release and expression of gap-junctional protein Cx43 in different set-ups of an in vitro astrocyte-microglia co-culture model of inflammation. null Methods null Primary rat co-cultures ...
Last. Mustofa Mustofa(UGM: Gadjah Mada University)H-Index: 12
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BACKGROUND As the life expectancy of elderly people has drastically increased, the incidence of cardiovascular and cerebrovascular diseases in this population has proportionally grown. Vascular cognitive impairment (VCI) refers to all forms of cognitive disorder associated with cerebrovascular disease. Homocysteine has recently been recognized as a contributor to the pathomechanisms involved in cognitive impairment. B vitamins, such as folic acid, are known to be effective in lowering homocystei...
BACKGROUND Anxiety disorders such as generalized anxiety disorder (GAD) impact 10% of the US population and many patients do not completely respond to first line-treatments (e.g. selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and psychotherapy). Given the dearth of evidence for non-pharmacologic, non-psychotherapeutic interventions, we performed a systematic review and meta-analysis of rTMS in adults with GAD. METHODS A systematic literature review using t...
BACKGROUND This double-blind (DB), randomized, parallel-group study was designed to evaluate efficacy and safety of paliperidone palmitate 6-month (PP6M) formulation relative to paliperidone palmitate 3-month (PP3M) formulation in patients with schizophrenia. METHODS Following screening, patients entered an open-label (OL)-maintenance phase and received 1 injection cycle of paliperidone palmitate 1-month (PP1M; 100 or 150 mg eq.) or PP3M (350 or 525 mg eq.). Clinically stable patients were rando...
#2Arpi Minassian(VA : United States Department of Veterans Affairs)H-Index: 34
Last. Jared W. Young(VHA: Veterans Health Administration)H-Index: 51
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BACKGROUND HIV-associated Neurocognitive Disorder (HAND) is commonly observed in persons living with HIV (PWH), and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also susceptible to alteration by cannabis and other drugs of abuse. PWH use cannabis at much higher rates than the general population, thus prioritizing the characterization of any interactions between HIV and cannabinoids on cognitively relevant systems. Prepulse in...
Background null Enhancement of NMDA receptor function using glycine-site agonist D-cycloserine is known to facilitate fear extinction providing a means to augment cognitive behavioral therapy in anxiety disorders. Recently a novel class of glycine-site agonists have been identified and we have found that the prototype, AICP is more effective than D-cycloserine in modulating neuronal function. null Methods null Using novel glycine-site agonist AICP, local infusion studies and genetic models, we e...
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