OBJECTIVE To identify classes of children exposed to distinct clusters of perinatal and familial risk factors at the time of birth, and examine relationships between class membership and a variety of adverse outcomes in childhood. DESIGN A prospective longitudinal study of children (and their parents) born between 2002 and 2004 and who have been followed-up until 12-13 years of age. A combination of latent class analysis and logistic regression analyses were used. RESULTS Adverse developmental, ...
#2Joseph H. Schneider(The University of Texas Southwestern Medical Center)H-Index: 9
Last. Luc P. Brion(The University of Texas Southwestern Medical Center)H-Index: 28
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BACKGROUND Neonatal hypoglycemia may affect long-term neurodevelopment. METHODS Quality improvement (QI) initiative for Mother-Baby-Unit (MBU) admissions (birthweight ≥ 2100 g; ≥35 weeks' gestation) over two epochs from 2016-2019 to reduce the frequency of early (≤3 h) neonatal hypoglycemia in small and large newborns. INTERVENTION New algorithm using Olsen's growth curves, hypoglycemia thresholds of null 3 to 24 h), feeding optimization and 24-hour glucose checks for small for gestational age a...
Last. Veena Manja(VHA: Veterans Health Administration)H-Index: 14
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While the opioid epidemic has garnered worldwide attention, increasing methamphetamine use has drawn less scrutiny. Methamphetamine is a highly addictive psychostimulant affecting people from all backgrounds and regions. It is a potent vasoconstrictor, is associated with arrhythmias and dilated cardiomyopathy. Cardiovascular disease-related mortality is a leading cause of death in methamphetamine users. Women of childbearing age increasingly use methamphetamine and continue during pregnancy. In ...
Objective null To establish whether administration of antenatal late preterm steroids to pregnant people with diabetes resulted in higher risk of neonatal hypoglycemia. null Study design null This is a retrospective cohort study of individuals with pre-gestational or gestational diabetes admitted between 34 0/7-36 6/7 weeks' gestation before and after introduction of an antenatal late preterm steroids protocol. The primary outcome was any neonatal blood glucose ≤ 60 mg/dL in the first 24 h of li...
#1Abby M Basalely(AECOM: Albert Einstein College of Medicine)
#2Russell Griffin(UAB: University of Alabama at Birmingham)H-Index: 32
Last. Kimberly J. Reidy(AECOM: Albert Einstein College of Medicine)H-Index: 20
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Objective null To determine the association of dysnatremia in the first postnatal week and risk of acute kidney injury (AKI) and mortality. null Study design null A secondary analysis of 1979 neonates in the AWAKEN cohort evaluated the association of dysnatremia with (1) AKI in the first postnatal week and (2) mortality, utilizing time-varying Cox proportional hazard models. null Result null Dysnatremia developed in 50.2% of the cohort and was not associated with AKI. Mortality was associated wi...
#1Wesley M. Jackson(UNC: University of North Carolina at Chapel Hill)H-Index: 20
#2Daniel Gonzalez(UNC: University of North Carolina at Chapel Hill)H-Index: 18
Last. Matthew M. Laughon(UNC: University of North Carolina at Chapel Hill)H-Index: 47
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Objective null To characterize the safety of sildenafil in premature infants. null Study design null A phase I, open-label trial of sildenafil in premature infants receiving sildenafil per usual clinical care (cohort 1) or receiving a single IV dose of sildenafil (cohort 2). Safety was evaluated based on adverse events (AEs), transaminase levels, and mean arterial pressure monitoring. null Results null Twenty-four infants in cohort 1 (n = 25) received enteral sildenafil. In cohort 2, infants rec...
#2Sara E. Rostas(BWH: Brigham and Women's Hospital)H-Index: 4
Last. Katherine Bell(BWH: Brigham and Women's Hospital)H-Index: 5
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BACKGROUND Acid-suppressing medications (ASMs) are commonly prescribed in the neonatal intensive care unit (NICU), in particular among preterm infants, despite well-established adverse effects and little evidence to support efficacy. LOCAL PROBLEM We sought to develop an initiative to reduce ASM exposure in our predominantly inborn level III NICU. Our specific aim was to reduce the number of nonindicated ASM prescriptions by 50% within a 12-month period. METHODS Our multidisciplinary team develo...
#1Bailey Wallace(CDC: Centers for Disease Control and Prevention)H-Index: 4
#2Daniel Chang(Oak Ridge Institute for Science and Education)
Last. Sascha R. Ellington(CDC: Centers for Disease Control and Prevention)H-Index: 32
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OBJECTIVE: To better understand COVID-19 in newborns, we compared in-hospital illness severity indicators by COVID-19 status during birth hospitalization. STUDY DESIGN: In a retrospective cohort of newborns born March-December 2020 in the Premier Healthcare Database Special COVID-19 Release, we classified COVID-19 status and severe illness indicators using ICD-CM-10 codes, laboratory data, and billing records. Illness severity indicators were compared by COVID-19 status, stratified by gestationa...
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