Original paper
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
Abstract
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all polymorphic residues are located in the peptide-binding groove, resulting in different peptide-binding preferences. Whether a single amino acid change can alter the peptide-binding repertoire of an HLA molecule has never been shown. To experimentally quantify the contribution of a single amino acid change to the peptide repertoire of even a single...
Paper Details
Title
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
Published Date
Jun 4, 2015
Journal
Volume
67
Issue
8
Pages
425 - 436
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Notes
History