Rates of re-traumatization among mentally ill-health patients have risen significantly over the past decade and clinical guidelines place mental health nurses at the heart of their care. To gather, analyse, and synthesize the evidence on people's experiences on re-traumatization in acute mental health inpatient settings. A systematic search for qualitative studies (CINAHL, MEDLINE, ASSIA, PsycINFO, and EMBASE) was conducted. Two authors independently assessed eligibility and appraised methodological quality using Joanna Briggs's quality appraisal tool and extracted data. The analysis followed the principles of interpretative synthesis. Fourteen papers were included for thematic synthesis. Three themes emerged: (1) Quality of staff interaction; (2) Specific interventions, (Sub-theme nature of symptoms); and (3) Nature of the environment. Our findings demonstrate that patients are experiencing re-traumatization in acute mental health inpatient settings and that there is little being done to prevent it from occurring. This study is the first to analyse the factors that contribute to re-traumatization and make recommendations to mental healthcare professionals to reduce the harmful practices in place in inpatient settings. It is suggested that training staff in trauma-informed care and allowing patients to be experts in their own care can reduce the rates of re-traumatization. Re-traumatization amongst people accessing mental healthcare has been receiving growing attention in research but despite this, trauma exposure and re-traumatization are often not recognized in acute mental health inpatient settings (Chambers et al., 2014; Duckworth & Follette, 2012; Read et al., 2007). Prevalence of trauma amongst people accessing mental health services is approximately between 70% and 90% (Copeland et al., 2018; Neill & Read, 2022; Phipps et al., 2019; Read et al., 2016, 2018). Successive studies have shown that people with mental health conditions have experienced traumatic events and how these experiences in particular chil...