Original paper
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
Abstract
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the 'don't-eat-me' cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic form of lung cancer. CD47 blockade potently enhances the local antitumor effects of radiotherapy in preclinical models of SCLC. Notably, CD47 blockade also stimulates off-target 'abscopal' effects...
Paper Details
Title
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
Published Date
Nov 21, 2022
Journal
Volume
3
Issue
11
Pages
1351 - 1366