Adhesion

Staphylococcus aureus

Biotechnology

Bacteria

Biology

Antimicrobial

Materials science

Surgery

Tannic acid

Wound dressing

Chitosan

Antibacterial activity

Poloxamer

Biochemistry

Polymer

Genetics

In vivo

Nanotechnology

Organic chemistry

Copolymer

Microbiology

Photothermal therapy

Bacterial growth

Composite material

Medicine

Chemistry

Wound healing

Carbohydrate Polymers

The design and development of smart shape-adaptable wound dressings with superior antimicrobial ability remain a challenge in therapeutic and clinical application. Herein, polydopamine/tannic acid/chitosan/poloxamer 407/188 hydrogel (PTCPP) was prepared with the aim of developing an in situ-formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. PTCPP possessed injectability, photothermal stability, sustained release properties and cytocompatibility. In vitro antibacterial results showed that the bactericidal rates of PTCPP against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) under NIR irradiation were 99.994 % and 99.91 %, respectively. In vivo experiments, PTCPP can adapt to shape of the wound, showing good adhesion, while promoting wound healing in bacterial infections. Therefore, PTCPP has potential application in the treatment of infectious wounds, and provides a strategic choice for developing antibacterial wound dressing combined with photothermal therapy.

Polydopamine/tannic acid/chitosan/poloxamer 407/188 thermosensitive hydrogel for antibacterial and wound healing