succinic acid

crude glycerol

yarrowia lipolytica

corynebacterium glutamicum

lipid production

metabolic engineering

fermentation broth

Trends in Biotechnology

Selection of the most appropriate microorganism is one of the key aspects for the industrial success of microbial bioprocesses.Yarrowia lipolytica has gained interest as a chassis strain in academia and industry because of its capacity to make products at high yields, use a broad range of substrates, and be genetically amenable.Y. lipolytica has many features that are desired at an industrial scale, such as safety, robustness, efficient and stable genetic modifications, capacity to use a variety of substrates, and ability to grow at very high cell density.To further improve the industrial use of Y. lipolytica, some characteristics must be improved through metabolic engineering, such as the high oxygen requirement, byproduct formation, and excessive foam synthesis. Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years, academic and industrial researchers have assessed its potential, developed synthetic biology techniques, improved its features, scaled its processes, and identified its limitations. Both publications and patents related to Y. lipolytica have shown a drastic increase during the past decade. Here, we discuss the characteristics of this yeast that make it suitable for industry and the remaining challenges for its wider use at large scale. We present evidence herein that shows the importance and potential of Y. lipolytica in bioproduction such that it may soon be one of the preferred choices of industry. Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years, academic and industrial researchers have assessed its potential, developed synthetic biology techniques, improved its features, scaled its processes, and identified its limitations. Both publications and patents related to Y. lipolytica have shown a drastic increase during the past decade. Here, ...

What makes Yarrowia lipolytica well suited for industry?