Neuron

Whitebirch et al. find increased intrinsic excitability and net synaptic excitation of CA2 PCs in hippocampal slices from epileptic mice. Chemogenetic inhibition of CA2 PCs in vivo reduces the frequency of spontaneous recurring seizures. Together, these data suggest that pathological hyperexcitability in CA2 circuitry may contribute to seizure activity in epilepsy.

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy