Internal medicine

Paneth cell

Tretinoin

Epithelium

Cell culture

Biology

Microbiology

Intraepithelial lymphocyte

Asthma

Immunology

Eosinophil

Small intestine

Enterocyte

Intestinal mucosa

Intestinal epithelium

Retinoic acid

Cell biology

Genetics

Biochemistry

Homeostasis

Medicine

Immune system

Cell Host & Microbe

The intestinal epithelium is a central node for communication between the microbiota and immune system. Cao et al. show that Faecalibaculum rodentium can promote epithelial proliferation and turnover by dampening retinoic acid production that supports survival of intestinal eosinophils, which in turn suppress pro-proliferative IFN-γ production.

Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis