Internal medicine

Pathology

Hepatocellular carcinoma

Biology

Neural stem cell

Oncology

Immunohistochemistry

Biopsy

Nestin

Malignancy

Stem cell

Intrahepatic Cholangiocarcinoma

Liver transplantation

Transplantation

Genetics

Medicine

Journal of Hepatology

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer (PLC) associated with a poor prognosis. Given the challenges in its identification and its clinical implications, biomarkers are critically needed. We aimed to investigate the diagnostic and prognostic value of the immunohistochemical expression of Nestin, a progenitor cell marker, in a large multicentric series of PLCs.

Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma