Internal medicine

AMPK

Bioinformatics

Phosphoproteomics

Biology

Gene

Endocrinology

Phosphorylation

Skeletal muscle

Regulator

Cell biology

Protein kinase A

Biochemistry

Medicine

Protein phosphorylation

Cell Metabolism

Blazev et al. characterized the signaling pathways regulated during three different types of exercise in human skeletal muscle. They identified the uncharacterized protein C18ORF25 as a target of AMPK and a new regulator of exercise capacity and skeletal muscle function.

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function