Messenger RNA

Translation (biology)

Transcriptome

Ribosome profiling

Open reading frame

ENCODE

Biology

Gene

Gene expression

Genome

Peptide sequence

Human genome

ORFS

Computational biology

Genetics

Ribosome

Molecular Cell

Chothani et al. evaluate ribosome-mRNA interactions across six cell types and five tissues and reveal 7,767 small regions outside of the protein-coding genome that are actively translated in humans. These include specifically expressed and highly conserved small open reading frames. The integration of proteomics reveals more than 600 small proteins.

A high-resolution map of human RNA translation