Adverse effect

Biology

Surgery

Inflammatory bowel disease

Dermatology

Tofacitinib

Rheumatoid arthritis

Paleontology

Pouch

Crohn's disease

Internal medicine

Series (stratigraphy)

Medicine

Pouchitis

Gastroenterology

Disease

Inflammatory Bowel Diseases

Lay Summary In this case series, 6 patients with chronic pouchitis (n = 3), cuffitis (n = 2), or Crohn’s-like disease of the pouch (n = 1) were treated with tofacitinib. One patient achieved clinical response; however, all patients ultimately discontinued therapy due to nonresponse or adverse events.

Tofacitinib for the Treatment of Pouch-Related Disorders: A Case Series