Pathology

Neuroscience

Disease

Transcription factor

Biology

Promoter

Gene

Gene expression

ATF3

Neurodegeneration

Retinal ganglion cell

Axon

Optic nerve

Cell biology

Genetics

Medicine

Neuron

By independent in vivo genetic screen and multi-omic analysis of injured retinal ganglion cells, Feng et al. identify four transcription factors, which act as complementary critical regulators of neuronal survival following injury. These genes regulate two distinct degenerative programs in response to extrinsic and intrinsic stressors, respectively.

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells