Internal medicine

Pathology

Disease

Macrophage

Fibrosis

Biology

In vitro

Immunology

Cirrhosis

Inflammation

Steatohepatitis

TREM2

Foam cell

Fatty liver

Microglia

Bone marrow

Biochemistry

Medicine

Journal of Hepatology

Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic steatohepatitis (NASH) and cirrhosis. Herein, we aimed to functionally characterize the role of bone marrow-derived TREM2-expressing macrophage populations in NASH.

Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH